Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models

Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na(+) channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive ca...

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Detalhes bibliográficos
Main Authors: Huang, Christopher L.-H., Lei, Lily, Matthews, Gareth D. K., Zhang, Yanmin, Lei, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2012
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390692/
https://ncbi.nlm.nih.gov/pubmed/22783200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00234
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