Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome

Mutations in SCN5A, the gene encoding the pore-forming subunit of cardiac Na(+) channels, cause a spectrum of arrhythmic syndromes. Of these, sinoatrial node (SAN) dysfunction occurs in patients with both loss- and gain-of-function SCN5A mutations. We explored for corresponding alterations in SAN fu...

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Detalhes bibliográficos
Main Authors: Wu, Jingjing, Zhang, Yanmin, Zhang, Xinzhao, Cheng, Longxian, Lammers, Wim J., Grace, Andrew A., Fraser, James A., Zhang, Henggui, Huang, Christopher L. -H., Lei, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330789/
https://ncbi.nlm.nih.gov/pubmed/22287583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00357.2011
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