Pathophysiological mechanisms of sino-atrial dysfunction and ventricular conduction disease associated with SCN5A deficiency: insights from mouse models

Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na+ channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive card...

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Main Authors: Christopher L-H Huang, Lily eLei, Gareth eMatthews, Yanmin eZhang, Ming eLei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012-07-01
Colecção:Frontiers in Physiology
Assuntos:
sinus node dysfunction
mouse genetic models
progressive cardiac conduction disease
SCN5A
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00234/full
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