Analysis of Nuclear Factor-κB (NF-κB) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-κB

Nuclear factor-κB (NF-κB) essential modulator (NEMO), a component of the inhibitor of κB kinase (IKK) complex, controls NF-κB signaling by binding to ubiquitin chains. Structural studies of NEMO provided a rationale for the specific binding between the UBAN (ubiquitin binding in ABIN and NEMO) domai...

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Main Authors: Kensche, Tobias, Tokunaga, Fuminori, Ikeda, Fumiyo, Goto, Eiji, Iwai, Kazuhiro, Dikic, Ivan
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390637/
https://ncbi.nlm.nih.gov/pubmed/22605335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347195
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