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LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

The transcription factor nuclear factor κB (NF-κB) regulates various cellular processes such as inflammation and apoptosis. The NF-κB essential modulator (NEMO/IKKγ) is indispensable for NF-κB activation by diverse stimuli including genotoxic stress. Here, we show that NEMO linear ubiquitination on...

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Bibliografiska uppgifter
Huvudupphovsmän: Niu, Jixiao, Shi, Yuling, Iwai, Kazuhiro, Wu, Zhao-Hui
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173792/
https://ncbi.nlm.nih.gov/pubmed/21811235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.264
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