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LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
The transcription factor nuclear factor κB (NF-κB) regulates various cellular processes such as inflammation and apoptosis. The NF-κB essential modulator (NEMO/IKKγ) is indispensable for NF-κB activation by diverse stimuli including genotoxic stress. Here, we show that NEMO linear ubiquitination on...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173792/ https://ncbi.nlm.nih.gov/pubmed/21811235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.264 |
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