SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

SHARPIN is a ubiquitin-binding and ubiquitin-like domain-containing protein which, when mutated in mice, results in immune system disorders and multiorgan inflammation(1,2). Here we report that SHARPIN functions as a novel component of the Linear Ubiquitin Chain Assembly Complex (LUBAC) and that the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ikeda, Fumiyo, Deribe, Yonathan Lissanu, Skånland, Sigrid S., Stieglitz, Benjamin, Grabbe, Caroline, Franz-Wachtel, Mirita, van Wijk, Sjoerd J. L., Goswami, Panchali, Nagy, Vanja, Terzic, Janos, Tokunaga, Fuminori, Androulidaki, Ariadne, Nakagawa, Tomoko, Pasparakis, Manolis, Iwai, Kazuhiro, Sundberg, John P., Schaefer, Liliana, Rittinger, Katrin, Macek, Boris, Dikic, Ivan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085511/
https://ncbi.nlm.nih.gov/pubmed/21455181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09814
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