Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation. Mice lacking Sharpin, a critical subunit of LUBAC, spontaneously develop inflammatory lesions in the skin and other o...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kumari, Snehlata, Redouane, Younes, Lopez-Mosqueda, Jaime, Shiraishi, Ryoko, Romanowska, Malgorzata, Lutzmayer, Stefan, Kuiper, Jan, Martinez, Conception, Dikic, Ivan, Pasparakis, Manolis, Ikeda, Fumiyo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225491/
https://ncbi.nlm.nih.gov/pubmed/25443631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03422
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