TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causes TNF-dependent multi-organ inflammation, characterized by dermatitis, liver inflammation, splenomegaly, and...

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Pubblicato in:eLife
Autori principali: Rickard, James A, Anderton, Holly, Etemadi, Nima, Nachbur, Ueli, Darding, Maurice, Peltzer, Nieves, Lalaoui, Najoua, Lawlor, Kate E, Vanyai, Hannah, Hall, Cathrine, Bankovacki, Aleks, Gangoda, Lahiru, Wong, Wendy Wei-Lynn, Corbin, Jason, Huang, Chunzi, Mocarski, Edward S, Murphy, James M, Alexander, Warren S, Voss, Anne K, Vaux, David L, Kaiser, William J, Walczak, Henning, Silke, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2014
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270099/
https://ncbi.nlm.nih.gov/pubmed/25443632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03464
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