Загрузка...

Mechanistic insights into the role of truncating PREX2 mutations in melanoma

PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Cell Oncol
Главный автор: Lissanu Deribe, Yonathan
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909440/
https://ncbi.nlm.nih.gov/pubmed/27314100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1160174
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!