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Mechanistic insights into the role of truncating PREX2 mutations in melanoma
PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to...
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| Publicado no: | Mol Cell Oncol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909440/ https://ncbi.nlm.nih.gov/pubmed/27314100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1160174 |
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