Lataa...
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcinoma. Here, genetic and biochemical analyses were co...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
|---|---|
| Päätekijät: | , , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2016
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780599/ https://ncbi.nlm.nih.gov/pubmed/26884185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513801113 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|