Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcinoma. Here, genetic and biochemical analyses were co...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Lissanu Deribe, Yonathan, Shi, Yanxia, Rai, Kunal, Nezi, Luigi, Amin, Samir B., Wu, Chia-Chin, Akdemir, Kadir C., Mahdavi, Mozhdeh, Peng, Qian, Chang, Qing Edward, Hornigold, Kirsti, Arold, Stefan T., Welch, Heidi C. E., Garraway, Levi A., Chin, Lynda
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780599/
https://ncbi.nlm.nih.gov/pubmed/26884185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513801113
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items