Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcinoma. Here, genetic and biochemical analyses were co...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Lissanu Deribe, Yonathan, Shi, Yanxia, Rai, Kunal, Nezi, Luigi, Amin, Samir B., Wu, Chia-Chin, Akdemir, Kadir C., Mahdavi, Mozhdeh, Peng, Qian, Chang, Qing Edward, Hornigold, Kirsti, Arold, Stefan T., Welch, Heidi C. E., Garraway, Levi A., Chin, Lynda
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780599/
https://ncbi.nlm.nih.gov/pubmed/26884185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513801113
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