Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcinoma. Here, genetic and biochemical analyses were co...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Lissanu Deribe, Yonathan, Shi, Yanxia, Rai, Kunal, Nezi, Luigi, Amin, Samir B., Wu, Chia-Chin, Akdemir, Kadir C., Mahdavi, Mozhdeh, Peng, Qian, Chang, Qing Edward, Hornigold, Kirsti, Arold, Stefan T., Welch, Heidi C. E., Garraway, Levi A., Chin, Lynda
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780599/
https://ncbi.nlm.nih.gov/pubmed/26884185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513801113
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы