Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint

In response to DNA damage, the eukaryotic genome surveillance system activates a checkpoint kinase cascade. In the fission yeast Schizosaccharomyces pombe, checkpoint protein Crb2 is essential for DNA damage-induced activation of downstream effector kinase Chk1. The mechanism by which Crb2 mediates...

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Detalhes bibliográficos
Main Authors: Qu, Meng, Yang, Bing, Tao, Li, Yates, John R., Russell, Paul, Dong, Meng-Qiu, Du, Li-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390401/
https://ncbi.nlm.nih.gov/pubmed/22792081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002817
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