Phosphorylation-dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(TopBP1)

The BRCT-domain protein, Rad4(TopBP1), facilitates activation of the DNA damage checkpoint in S. pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR)-Rad26(ATRIP) kinase complex and Crb2(53BP1) mediator. We have now determined crystal structures of the BRCT repeats of Rad4(TopBP1), r...

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Udgivet i:Mol Cell
Main Authors: Qu, Meng, Rappas, Mathieu, Wardlaw, Christopher P., Garcia, Valerie, Ren, Jing-Yi, Day, Matthew, Carr, Antony M., Oliver, Antony W., Du, Li-Lin, Pearl, Laurence H.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944838/
https://ncbi.nlm.nih.gov/pubmed/24074952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.08.030
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