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Phosphorylation-dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(TopBP1)
The BRCT-domain protein, Rad4(TopBP1), facilitates activation of the DNA damage checkpoint in S. pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR)-Rad26(ATRIP) kinase complex and Crb2(53BP1) mediator. We have now determined crystal structures of the BRCT repeats of Rad4(TopBP1), r...
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Publicado no: | Mol Cell |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4944838/ https://ncbi.nlm.nih.gov/pubmed/24074952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.08.030 |
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