Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B

BACKGROUND: Although the peptidyl-prolyl isomerase, cyclophilin-A (peptidyl-prolyl isomerase, PPIA), has been studied for decades in the context of its intracellular functions, its extracellular roles as a major contributor to both inflammation and multiple cancers have more recently emerged. A wide...

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Detalhes bibliográficos
Main Authors: Bahmed, Karim, Henry, Curtis, Holliday, Michael, Redzic, Jasmina, Ciobanu, Madalina, Zhang, Fengli, Weekes, Colin, Sclafani, Robert, DeGregori, James, Eisenmesser, Elan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390265/
https://ncbi.nlm.nih.gov/pubmed/22631225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-12-19
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