Primary cilia regulate mTORC1 activity and cell size through Lkb1

The mTOR pathway is the central regulator of cell size(1). External signals from growth factors and nutrients converge on the mTORC1 multi-protein complex to modulate downstream targets, but how the different inputs are integrated and translated into specific cellular responses is incompletely under...

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Main Authors: Boehlke, Christopher, Kotsis, Fruzsina, Patel, Vishal, Braeg, Simone, Voelker, Henriette, Bredt, Saskia, Beyer, Theresa, Janusch, Heike, Hamann, Christoph, Gödel, Markus, Müller, Klaus, Herbst, Martin, Hornung, Miriam, Doerken, Mara, Köttgen, Michael, Nitschke, Roland, Igarashi, Peter, Walz, Gerd, Kuehn, E. Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390256/
https://ncbi.nlm.nih.gov/pubmed/20972424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2117
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