Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load

Body copper homeostasis is regulated by the liver, which removes excess copper via bile. In Wilson's disease (WD), this function is disrupted due to inactivation of the copper transporter ATP7B resulting in hepatic copper overload. High urinary copper is a diagnostic feature of WD linked to liv...

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Autors principals: Gray, Lawrence W., Peng, Fangyu, Molloy, Shannon A., Pendyala, Venkata S., Muchenditsi, Abigael, Muzik, Otto, Lee, Jaekwon, Kaplan, Jack H., Lutsenko, Svetlana
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390108/
https://ncbi.nlm.nih.gov/pubmed/22802922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038327
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