Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load

Body copper homeostasis is regulated by the liver, which removes excess copper via bile. In Wilson's disease (WD), this function is disrupted due to inactivation of the copper transporter ATP7B resulting in hepatic copper overload. High urinary copper is a diagnostic feature of WD linked to liv...

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Main Authors: Gray, Lawrence W., Peng, Fangyu, Molloy, Shannon A., Pendyala, Venkata S., Muchenditsi, Abigael, Muzik, Otto, Lee, Jaekwon, Kaplan, Jack H., Lutsenko, Svetlana
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390108/
https://ncbi.nlm.nih.gov/pubmed/22802922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038327
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