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Actinomycin D induced DNase I cleavage enhancement caused by sequence specific propagation of an altered DNA structure.

Two DNA hexadecamers containing one central 5'-GC-3' base step have been examined by footprinting methodology in the presence and absence of actinomycin D. The results of these studies, coupled with imino proton NMR measurements indicate that the antitumor drug causes a change in DNA confo...

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Main Authors: Huang, Y Q, Rehfuss, R P, LaPlante, S R, Boudreau, E, Borer, P N, Lane, M J
Formato: Artigo
Idioma:Inglês
Publicado: 1988
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC339000/
https://ncbi.nlm.nih.gov/pubmed/3205740
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