Actinomycin D induced DNase I cleavage enhancement caused by sequence specific propagation of an altered DNA structure.

Two DNA hexadecamers containing one central 5'-GC-3' base step have been examined by footprinting methodology in the presence and absence of actinomycin D. The results of these studies, coupled with imino proton NMR measurements indicate that the antitumor drug causes a change in DNA confo...

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Bibliographic Details
Main Authors: Huang, Y Q, Rehfuss, R P, LaPlante, S R, Boudreau, E, Borer, P N, Lane, M J
Format: Artigo
Language:Inglês
Published: 1988
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC339000/
https://ncbi.nlm.nih.gov/pubmed/3205740
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