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Actinomycin D induced DNase I hypersensitivity and asymmetric structure transmission in a DNA hexadecamer.
DNase I cleavage rates and nmr chemical shifts are shown to change for DNA sequences distal to an intercalated actinomycin D molecule in a duplex hexadecamer upon drug binding. Both sets of observations suggest that the source of these changes is a DNA-mediated structural response. The nmr results i...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
1991
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC333724/ https://ncbi.nlm.nih.gov/pubmed/2017369 |
| Etykiety: |
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