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Actinomycin D induced DNase I hypersensitivity and asymmetric structure transmission in a DNA hexadecamer.
DNase I cleavage rates and nmr chemical shifts are shown to change for DNA sequences distal to an intercalated actinomycin D molecule in a duplex hexadecamer upon drug binding. Both sets of observations suggest that the source of these changes is a DNA-mediated structural response. The nmr results i...
Shranjeno v:
| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1991
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC333724/ https://ncbi.nlm.nih.gov/pubmed/2017369 |
| Oznake: |
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