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Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe
Further chemical optimization of the MLSCN/MLPCN probe ML077 (KCC2 IC(50) = 537 nM) proved to be challenging as the effort was characterized by steep SAR. However, a multidimensional iterative parallel synthesis approach proved productive. Herein we report the discovery and SAR of an improved novel...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389279/ https://ncbi.nlm.nih.gov/pubmed/22727639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.126 |
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