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Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: Decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)?
Inappropriate survival signaling after DNA damage may facilitate clonal expansion of genetically compromised cells, and it is known that protein tyrosine phosphatase (PTP) inhibitors activate key survival pathways. In this study we employed the genotoxicant, hexavalent chromium [Cr(VI)], which is a...
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主要な著者: | , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2012
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389208/ https://ncbi.nlm.nih.gov/pubmed/22583656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2012.05.001 |
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