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Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: Decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)?

Inappropriate survival signaling after DNA damage may facilitate clonal expansion of genetically compromised cells, and it is known that protein tyrosine phosphatase (PTP) inhibitors activate key survival pathways. In this study we employed the genotoxicant, hexavalent chromium [Cr(VI)], which is a...

詳細記述

保存先:
書誌詳細
主要な著者: Kost, Gina Chun, Patierno, Steven R., Wise, Sandra S., Holmes, Amie L., Wise, John Pierce, Ceryak, Susan
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389208/
https://ncbi.nlm.nih.gov/pubmed/22583656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2012.05.001
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