Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: Decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)?

Inappropriate survival signaling after DNA damage may facilitate clonal expansion of genetically compromised cells, and it is known that protein tyrosine phosphatase (PTP) inhibitors activate key survival pathways. In this study we employed the genotoxicant, hexavalent chromium [Cr(VI)], which is a...

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Sonraí Bibleagrafaíochta
Main Authors: Kost, Gina Chun, Patierno, Steven R., Wise, Sandra S., Holmes, Amie L., Wise, John Pierce, Ceryak, Susan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389208/
https://ncbi.nlm.nih.gov/pubmed/22583656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2012.05.001
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