Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

The invasiveness of tumour cells depends on changes in cell shape, polarity and migration. Mutant p53 induces enhanced tumour metastasis in mice, and human cells overexpressing p53R273H have aberrant polarity and increased invasiveness, demonstrating the ‘gain of function' of mutant p53 in carc...

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Detalhes bibliográficos
Main Authors: Coffill, Cynthia R, Muller, Patricia A J, Oh, Hue Kian, Neo, Suat Peng, Hogue, Kelly A, Cheok, Chit Fang, Vousden, Karen H, Lane, David P, Blackstock, Walter P, Gunaratne, Jayantha
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388785/
https://ncbi.nlm.nih.gov/pubmed/22653443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.74
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