Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

The invasiveness of tumour cells depends on changes in cell shape, polarity and migration. Mutant p53 induces enhanced tumour metastasis in mice, and human cells overexpressing p53R273H have aberrant polarity and increased invasiveness, demonstrating the ‘gain of function' of mutant p53 in carc...

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Autors principals: Coffill, Cynthia R, Muller, Patricia A J, Oh, Hue Kian, Neo, Suat Peng, Hogue, Kelly A, Cheok, Chit Fang, Vousden, Karen H, Lane, David P, Blackstock, Walter P, Gunaratne, Jayantha
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388785/
https://ncbi.nlm.nih.gov/pubmed/22653443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.74
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