Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter

YM155, a novel survivin suppressant, shows potent antitumor activity against various human cancers and is currently in phase II clinical trials. In this study, we investigated whether YM155 selectively inhibits survivin transcription. We hypothesize that inhibition of survivin transcription plays a...

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Bibliografske podrobnosti
Main Authors: Cheng, Qiuying, Ling, Xiang, Haller, Andrew, Nakahara, Takahito, Yamanaka, Kentaro, Kita, Aya, Koutoku, Hiroshi, Takeuchi, Masahiro, Brattain, Michael G, Li, Fengzhi
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2012
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388737/
https://ncbi.nlm.nih.gov/pubmed/22773958
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