Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition

Twist1 is highly expressed in primary and metastatic non-small cell lung cancer (NSCLC), and thus acts as a critical target for lung cancer chemotherapy. In the current study, we investigated the underlying mechanism initiated by silencing of Twist1 that sensitizes NSCLC cells to cisplatin. Silencin...

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Autori principali: Jin, H-O, Hong, S-E, Woo, S-H, Lee, J-H, Choe, T-B, Kim, E-K, Noh, W-C, Lee, J-K, Hong, S-I, Kim, J-I, Park, I-C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388235/
https://ncbi.nlm.nih.gov/pubmed/22673193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.63
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