Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development

The Aurora-A kinase gene is frequently amplified and/or over-expressed in a variety of human cancers, leading to major efforts to develop therapeutic agents targeting this pathway. Here we demonstrate that Aurora-A is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7...

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Hlavní autoři: Kwon, Yong-Won, Kim, Il-Jin, Wu, Di, Lu, Jing, Stock, William A, Liu, Yueyong, Huang, Yurong, Kang, Hio Chung, DelRosario, Reyno, Jen, Kuang-Yu, Perez-Losada, Jesus, Wei, Guangwei, Balmain, Allan, Mao, Jian-Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388112/
https://ncbi.nlm.nih.gov/pubmed/22513362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0025
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