Single Nucleotide Polymorphism (SNP)-Based Loss of Heterozygosity (LOH) Testing by Real Time PCR in Patients Suspect of Myeloproliferative Disease

During tumor development, loss of heterozygosity (LOH) often occurs. When LOH is preceded by an oncogene activating mutation, the mutant allele may be further potentiated if the wild-type allele is lost or inactivated. In myeloproliferative neoplasms (MPN) somatic acquisition of JAK2V617F may be fol...

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Main Authors: Huijsmans, Cornelis J. J., Poodt, Jeroen, Damen, Jan, van der Linden, Johannes C., Savelkoul, Paul H. M., Pruijt, Johannes F. M., Hilbink, Mirrian, Hermans, Mirjam H. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388082/
https://ncbi.nlm.nih.gov/pubmed/22768290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038362
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