Direct Inference of SNP Heterozygosity Rates and Resolution of LOH Detection

Single nucleotide polymorphisms (SNPs) have been increasingly utilized to investigate somatic genetic abnormalities in premalignancy and cancer. LOH is a common alteration observed during cancer development, and SNP assays have been used to identify LOH at specific chromosomal regions. The design of...

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Detalhes bibliográficos
Main Authors: Li, Xiaohong, Self, Steven G, Galipeau, Patricia C, Paulson, Thomas G, Reid, Brian J
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2098867/
https://ncbi.nlm.nih.gov/pubmed/18052545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030244
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