Sensitive Detection and Quantification of the JAK2V617F Allele by Real-Time PCR: Blocking Wild-Type Amplification by Using a Peptide Nucleic Acid Oligonucleotide

A single G-to-T missense mutation in the gene for the JAK2 tyrosine kinase, leading to a V617F amino acid substitution, is commonly found in several myeloproliferative neoplasms. Reliable quantification of this mutant allele is of increasing clinical and therapeutic interest in predicting and diagno...

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Autors principals: Huijsmans, Cornelis J.J., Poodt, Jeroen, Savelkoul, Paul H.M., Hermans, Mirjam H.A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2011
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157608/
https://ncbi.nlm.nih.gov/pubmed/21723417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2011.04.002
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