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Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase
BACKGROUND: Hepatitis C is a treatment-resistant disease affecting millions of people worldwide. The hepatitis C virus (HCV) genome is a single-stranded RNA molecule. After infection of the host cell, viral RNA is translated into a polyprotein that is cleaved by host and viral proteinases into funct...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3388044/ https://ncbi.nlm.nih.gov/pubmed/22768327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040029 |
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