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Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

[Image: see text] Aggregation and accumulation of the microtubule-associated protein tau are associated with cognitive decline and neuronal degeneration in Alzheimer's disease and other tauopathies. Thus, preventing the transition of tau from a soluble state to insoluble aggregates and/or rever...

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Autori principali: Patterson, Kristina R., Ward, Sarah M., Combs, Benjamin, Voss, Kellen, Kanaan, Nicholas M., Morfini, Gerardo, Brady, Scott T., Gamblin, T. Chris, Binder, Lester I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387688/
https://ncbi.nlm.nih.gov/pubmed/22039833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2009147
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