Imidazoquinoline TLR8 agonists activate human newborn monocytes and dendritic cells via adenosine-refractory and caspase-1-dependent pathways

BACKGROUND: Newborns suffer frequent infection and manifest impaired vaccine responses, motivating a search for neonatal vaccine adjuvants. Alum is a neonatal adjuvant, but may confer a Th2 bias. Toll-like receptor (TLR) agonists are candidate adjuvants, but human neonatal cord blood monocytes (Mos)...

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Autors principals: Philbin, Victoria J., Dowling, David J., Gallington, Leighanne C., Cortés, Guadalupe, Tan, Zhen, Suter, Eugénie E., Chi, Kevin W., Shuckett, Ariel, Stoler-Barak, Liat, Tomai, Mark, Miller, Richard L., Mansfield, Keith, Levy, Ofer
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387351/
https://ncbi.nlm.nih.gov/pubmed/22521247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.02.042
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