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Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. A low dose (approxima...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3387277/ https://ncbi.nlm.nih.gov/pubmed/21830940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1103849 |
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