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T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Tumor immunotherapy with T lymphocytes, which can recognize and destroy malignant cells, has been limited by the ability to isolate and expand T cells restricted to tumor-associated antigens. Chimeric antigen receptors (CARs) composed of antibody binding domains connected to domains that activate T...

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Detalhes bibliográficos
Main Authors: Kalos, Michael, Levine, Bruce L., Porter, David L., Katz, Sharyn, Grupp, Stephan A., Bagg, Adam, June, Carl H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393096/
https://ncbi.nlm.nih.gov/pubmed/21832238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002842
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