Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

Patients with multiply relapsed or refractory chronic lymphocytic leukemia (CLL) have a poor prognosis. Chimeric antigen receptor (CAR)–modified T cells targeting CD19 have the potential to improve on the low complete response rates with conventional therapies by inducing sustained remissions in pat...

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Udgivet i:Sci Transl Med
Main Authors: Porter, David L., Hwang, Wei-Ting, Frey, Noelle V., Lacey, Simon F., Shaw, Pamela A., Loren, Alison W., Bagg, Adam, Marcucci, Katherine T., Shen, Angela, Gonzalez, Vanessa, Ambrose, David, Grupp, Stephan A., Chew, Anne, Zheng, Zhaohui, Milone, Michael C., Levine, Bruce L., Melenhorst, Jan J., June, Carl H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909068/
https://ncbi.nlm.nih.gov/pubmed/26333935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac5415
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