AID-Targeting and Hypermutation of Non-Immunoglobulin Genes Does Not Correlate with Proximity to Immunoglobulin Genes in Germinal Center B Cells

Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of expressed genes in germinal center B cells ar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gramlich, Hillary Selle, Reisbig, Tara, Schatz, David G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387148/
https://ncbi.nlm.nih.gov/pubmed/22768095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039601
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