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Independent regulation of tumor cell migration by matrix stiffness and confinement

Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cul...

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Detalhes bibliográficos
Main Authors: Pathak, Amit, Kumar, Sanjay
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387066/
https://ncbi.nlm.nih.gov/pubmed/22689955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118073109
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