Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

Cell migration on 2D surfaces is governed by a balance between counteracting tractile and adhesion forces. Although biochemical factors such as adhesion receptor and ligand concentration and binding, signaling through cell adhesion complexes, and cytoskeletal structure assembly/disassembly have been...

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Main Authors: Zaman, Muhammad H., Trapani, Linda M., Sieminski, Alisha, MacKellar, Drew, Gong, Haiyan, Kamm, Roger D., Wells, Alan, Lauffenburger, Douglas A., Matsudaira, Paul
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544144/
https://ncbi.nlm.nih.gov/pubmed/16832052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604460103
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