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Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine

Bendamustine (BDM) is an active chemotherapeutic agent approved in the U. S. for treating chronic lymphocytic leukemia and non-Hodgkin lymphoma. Its chemical structure suggests it may have alkylator and anti-metabolite activities; however the precise mechanism of action is not well understood. Here...

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Detalhes bibliográficos
Main Authors: Beeharry, Neil, Rattner, Jerome B., Bellacosa, Alfonso, Smith, Mitchell R., Yen, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386996/
https://ncbi.nlm.nih.gov/pubmed/22768280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040342
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