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Centromere fragmentation is a common mitotic defect of S and G(2) checkpoint override
DNA damaging agents, including those used in the clinic, activate cell cycle checkpoints, which blocks entry into mitosis. Given that checkpoint override results in cell death via mitotic catastrophe, inhibitors of the DNA damage checkpoint are actively being pursued as chemosensitization agents. He...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3680538/ https://ncbi.nlm.nih.gov/pubmed/23624842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24740 |
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