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Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine

Bendamustine (BDM) is an active chemotherapeutic agent approved in the U. S. for treating chronic lymphocytic leukemia and non-Hodgkin lymphoma. Its chemical structure suggests it may have alkylator and anti-metabolite activities; however the precise mechanism of action is not well understood. Here...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Beeharry, Neil, Rattner, Jerome B., Bellacosa, Alfonso, Smith, Mitchell R., Yen, Timothy J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386996/
https://ncbi.nlm.nih.gov/pubmed/22768280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040342
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