Oxidative stress fuels Trypanosoma cruzi infection in mice

Oxidative damage contributes to microbe elimination during macrophage respiratory burst. Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses, including the expression of heme-oxygenase–1 (HO-1). Unexpectedly, the activation of NRF2 and HO-1 reduces infection by a num...

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Hlavní autoři: Paiva, Claudia N., Feijó, Daniel F., Dutra, Fabianno F., Carneiro, Vitor C., Freitas, Guilherme B., Alves, Letícia S., Mesquita, Jacilene, Fortes, Guilherme B., Figueiredo, Rodrigo T., Souza, Heitor S.P., Fantappié, Marcelo R., Lannes-Vieira, Joseli, Bozza, Marcelo T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386808/
https://ncbi.nlm.nih.gov/pubmed/22728935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58525
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