Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors

Due to structural and mechanistic differences between eukaryotic and prokaryotic fatty acid synthesis enzymes, the bacterial pathway, FAS-II, is an attractive target for the design of antimicrobial agents. We have previously reported the identification of a novel series of benzimidazole compounds wi...

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Bibliographic Details
Main Authors: Mehboob, Shahila, Hevener, Kirk E, Truong, Kent, Boci, Teuta, Santarsiero, Bernard D, Johnson, Michael E
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386789/
https://ncbi.nlm.nih.gov/pubmed/22642319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300489v
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