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Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2
Hereditary hemochomatosis (HH) is caused by mutations in several genes, including HFE and transferrin receptor-2 (TFR2). Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in syste...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386558/ https://ncbi.nlm.nih.gov/pubmed/22460705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23173 |
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