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Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

Hereditary hemochomatosis (HH) is caused by mutations in several genes, including HFE and transferrin receptor-2 (TFR2). Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in syste...

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Main Authors: Schmidt, Paul J., Fleming, Mark D.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386558/
https://ncbi.nlm.nih.gov/pubmed/22460705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23173
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