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Structure-activity-relationship study of N(6)-(2(4-(1H-indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: Development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization

In our effort to develop multifunctional drugs against Parkinson’s disease, a structure-activity-relationship study was carried out based on our hybrid molecular template targeting D2/D3 receptors. Competitive binding with [(3)H]spiroperidol was used to evaluate affinity (K(i)) of test compounds. Fu...

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Detalhes bibliográficos
Main Authors: Johnson, Mark, Antonio, Tamara, Reith, Maarten E. A., Dutta, Aloke K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386472/
https://ncbi.nlm.nih.gov/pubmed/22642365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300268s
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