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Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme

For a quantitative understanding of the process of adaptation, we need to understand its “raw material,” that is, the frequency and fitness effects of beneficial mutations. At present, most empirical evidence suggests an exponential distribution of fitness effects of beneficial mutations, as predict...

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Main Authors: Schenk, Martijn F., Szendro, Ivan G., Krug, Joachim, de Visser, J. Arjan G. M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386231/
https://ncbi.nlm.nih.gov/pubmed/22761587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002783
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