Hypoxia Moderates γ(1)34.5-Deleted Herpes Simplex Virus Oncolytic Activity in Human Glioma Xenoline Primary Cultures

Hypoxia plays a critical role in the tumor microenvironment of high-grade gliomas by promoting the glioma stem cell (GSC)-like phenotype, which displays resistance to standard therapies. We tested three glioblastoma multiforme xenograft lines (xenolines) against γ(1)34.5-deleted recombinant oncolyti...

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Bibliographic Details
Main Authors: Friedman, Gregory K, Haas, Marilyn C, Kelly, Virginia M, Markert, James M, Gillespie, George Yancey, Cassady, Kevin A
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384274/
https://ncbi.nlm.nih.gov/pubmed/22741039
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