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Wide-Open Flaps are Key to Urease Activity
Substrate ingress and product egress from the active site of urease is tightly controlled by an active site flap. Molecular dynamics simulations of urease reveal a previously unobserved, wide-open flap state that, unlike the well-characterized closed and open states, allows ready access to the metal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384008/ https://ncbi.nlm.nih.gov/pubmed/22670767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3043239 |
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