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NRF2 DEFICIENCY IN MYELOID CELLS IS NOT SUFFICIENT TO PROTECT MICE FROM HFD-INDUCED ADIPOSE TISSUE INFLAMMATION AND INSULIN RESISTANCE
Activation of the transcription factor NF-E2 related factor 2 (Nrf2) by oxidative stress induces the expression of a variety of antioxidant and anti-inflammatory genes. Yet, genetic ablation of Nrf2 was shown to protect mice from high-fat diet (HFD)-induced obesity and insulin resistance. The mechan...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383807/ https://ncbi.nlm.nih.gov/pubmed/22370093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.022 |
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